PAIN RELIEF/ARTHRITIS/OSTEOARTHRITIS/RHEUMATOID ARTHRITIS
Kenareh R, Mirmohammadi SJ, Khatibi A, Shamsi F, Mehrparvar AH. The Comparison of The Efficacy of Photobiomodulation and Ultrasound in the Treatment of Chronic Non-specific Neck Pain: A Randomized Single-Blind Controlled Trial. Journal of Lasers in Medical Sciences. 2021 ;12:e20. DOI: 10.34172/jlms.2021.20.
Acute Low Back Pain with Radiculopathy: A Double-Blind, Randomized, Placebo-Controlled Study
Ljubica M. Konstantinovic, Zeljko M. Kanjuh, Andjela N. Milovanovic, Milisav R. Cutovic, Aleksandar G. Djurovic, Viktorija G. Savic, Aleksandra S. Dragin, and Nesa D. Milovanovic
Photomedicine and Laser Surgery 2010 28:4, 553-560
- A randomized, double-blind, placebo-controlled trial
- n=546
- Statistically significant in all outcomes measured (p < 0.001)
- Results show better improvement in acute LBP treated with LLLT
- Systematic review and meta-analysis
- We solely included randomized placebo-controlled trials involving participants with KOA according to the American College of Rheumatology and/or Kellgren/Lawrence criteria, in which LLLT was applied to participants’ knee(s)
- 22 trials (n=1063) were meta-analysed. Risk of bias was insignificant. Overall, pain was significantly reduced by LLLT compared with placebo at the end of therapy.
- LLLT is a non-invasive treatment modality,(1-2) which has been reported to induce anti-inflammatory effects. (2–7)
- 1. Rayegani SM, Raeissadat SA, Heidari S, et al. Safety and effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. J Lasers Med Sci 2017;8:S12–19.
- 2. Hamblin MR. Can osteoarthritis be treated with light? Arthritis Res Ther 2013;15.
- 3. Tomazoni SS, Leal-Junior ECP, Pallotta RC, et al. Effects of photobiomodulation therapy, pharmacological therapy, and physical exercise as single and/or combined treatment on the inflammatory response induced by experimental osteoarthritis. Lasers Med Sci 2017;32:101–8.
- 4. Tomazoni SS, Leal-Junior ECP, Frigo L, et al. Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain. J Biomed Opt 2016;21:108001.
- 5. Wang P, Liu C, Yang X, et al. Effects of low-level laser therapy on joint pain, synovitis, anabolic, and catabolic factors in a progressive osteoarthritis rabbit model. Lasers Med Sci 2014;29:1875–85.
- 6. Assis L, Almeida T, Milares LP, et al. Musculoskeletal atrophy in an experimental model of knee osteoarthritis: the effects of exercise training and low-level laser therapy. Am J Phys Med Rehabil 2015;94:609–16.
- 7. Pallotta RC, Bjordal JM, Frigo L, et al. Infrared (810-nm) low-level laser therapy on rat experimental knee inflammation. Lasers Med Sci 2012;27:71–8.
HEALING
Spitler R, Ho H, Norpetlian F, et al. Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 2015;20(5):051022. doi:10.1117/1.JBO.20.5.051022
Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J. Effect of NASA light-emitting diode irradiation on wound healing. J Clin Laser Med Surg. 2001 Dec;19(6):305-14. doi: 10.1089/104454701753342758.
José Carlos Tatmatsu-Rocha, et al. Low-level laser therapy (904nm) can increase collagen and reduce oxidative and nitrosative stress in diabetic wounded mouse skin, Journal of Photochemistry and Photobiology B: Biology, Volume 164, 2016, Pages 96-102, ISSN 1011-1344, doi: 10.1016/j.jphotobiol.2016.09.01.
INFLAMMATION
CANCER/CANCER CARE
- Conclusions: PBM therapy may have benefits in cancer patients and should be further investigated.
Pereira, S.T., Silva, C.R., Nuñez, S.C. and Ribeiro, M.S. (2021), Safety and Clinical Impact of a Single Red Light Irradiation on Breast Tumor-Bearing Mice. Photochem Photobiol, 97: 435-442. https://doi.org/10.1111/php.13338
Light therapy fast-tracks healing of skin damage from cancer radiation therapy
https://www.sciencedaily.com/releases/2022/01/220127104305.htm
- Light therapy may accelerate the healing of skin damage from radiation therapy by up to 50%.
- LED red light has been reported to have many health benefits. The present study was conducted to characterise anti-proliferation properties of four LED red light wavelengths (615, 630, 660 and 730 nm) against non-triple negative (MCF-7) and triple negative (MDA-MB-231) breast cancer-origin cell lines.
- It has been shown by MTT assay that at 24 h post-exposure time point, only LED red light with wavelength 660 nm possessed anti-proliferative effects against both cell lines with 40% reduction of cell viability. The morphology of LED 660 nm irradiated cells was found flatten with enlarged cell size, typical characteristic of cell senescent. Indications of autophagy activities following the irradiation
- an increase number of autophagosomes formation in LED 660 nm irradiated cells compared to control cells.
- Electron dense bodies observed in these cells under TEM micrographs, leading to the conclusion that LED 660 nm irradiation promoted anti-proliferative activities through autophagy in breast cancer-origin cells.
- Positive effects of LED-based radiationin cancer research with little health hazards being reported.
- These findings have suggested that LED 660 nm might be developed and be employed as an alternative cancer treatment method in future.
- Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer therapy with few efficacious treatments.
- PBM produced significant reduction in neuropathy symptoms.
MITOCHONDRIA
WEIGHT LOSS/BODY CONTOURING
- Double-blind, randomized, placebo-controlled trial
- There were no negative findings.
- n=67
- Results: Participants in the treatment group demonstrated an overall reduction in total circumference across all three sites of 3.51 in.
- (P < 0.001) compared with control subjects who revealed a 0.684 reduction (P < 0.071745). Test group participants demonstrated a reduction of 0.98 in. (P < 0.0001) across the waist, 1.05 in. (P < 0.01) across the hip, and 0.85 in. (P < 0.01) and 0.65 in. (P < 0.01) across the right and left thighs from baseline to 2 weeks (end of treatment).
- Participants were retrospectively assessed at an individual clinic in the United States.
- Compared with baseline, a statistically significant 2.99 in. (7.59 cm) mean LOSS was observed at the post-procedure evaluation point (P < 0.0001). When analyzed individually, the waist, hips, and thighs each reported a statistically significant reduction of 1.12, 0.769, and 1.17, respectively.
- There were no negative findings.
- n=86
DEPRESSION
Cassano P, Petrie SR, Mischoulon D, Cusin C, Katnani H, Yeung A, De Taboada L, Archibald A, Bui E, Baer L, Chang T, Chen J, Pedrelli P, Fisher L, Farabaugh A, Hamblin MR, Alpert JE, Fava M, Iosifescu DV. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomed Laser Surg. 2018 Dec;36(12):634-646. doi: 10.1089/pho.2018.4490. Epub 2018 Oct 20. PMID: 30346890; PMCID: PMC7864111.
- Double-blind, sham-controlled study on the safety and efficacy [change in Hamilton Depression Rating Scale (HAM-D17) total score at end-point] of adjunct t-PBM NIR, 823nm
- t-PBM with NIR light demonstrated antidepressant properties with a medium to large effect size in patients with MDD.
FERTILITY (Female and Male)
Salman Yazdi R, Bakhshi S, Jannat Alipoor F, Akhoond MR, Borhani S, Farrahi F, Lotfi Panah M, Sadighi Gilani MA. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014 Jan;29(1):97-104. doi: 10.1007/s10103-013-1276-7. Epub 2013 Feb 14. PMID: 23407899.
- Results showed that irradiating human sperm with low-level 830-nm diode laser can improve their progressive motility depending on both laser density and post-exposure time.
- n=22
COSMETIC/COLLAGEN/ANTI-AGING
Wunsch, Alexander, and Karsten Matuschka. “A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.” Photomedicine and laser surgery vol. 32,2 (2014): 93-100. doi:10.1089/pho.2013.3616
- The treated subjects experienced significantly improved skin complexion and skin feeling, assessed skin roughness, and ultrasonographic measured collagen density. The blinded clinical evaluation of photographs confirmed significant improvement in the intervention groups compared with the control.
- There were no negative findings.
- n=136
COVID/LONG COVID
FIBROMYALGIA
SEXUAL FUNCTION
INSOMNIA
INSULIN RESISTANCE
ATOPIC DERMATITIS
Morita H, Kohno J, Hori M, Kitano Y. Clinical application of low reactive level laser therapy (LLLT) for atopic dermatitis. Keio J Med. 1993;42(4):174-176. doi:10.2302/kjm.42.174
EDEMA
Oliveira CG, Freitas MF, de Sousa MVP, Giorgi R, Chacur M. Photobiomodulation reduces nociception and edema in a CFA-induced muscle pain model: effects of LLLT and LEDT. Photochem Photobiol Sci. 2020;19(10):1392-1401. doi:10.1039/d0pp00037j
MUSCLE CONDITIONING
Agrawal T, Gupta GK, Rai V, Carroll JD, Hamblin MR. Pre-Conditioning with Low-Level Laser (Light) Therapy: Light before the Storm. Dose-Response. October 2014. doi:10.2203/dose-response.14-032.Agrawal.
HAIR GROWTH
Pillai JK, Mysore V. Role of Low-Level Light Therapy (LLLT) in Androgenetic Alopecia. J Cutan Aesthet Surg. 2021;14(4):385-391. doi:10.4103/JCAS.JCAS_218_20
Mai-Yi Fan, Sabrina PhD*; Cheng, Yu-Pin MD†; Lee, Ming-Yung PhD‡; Lin, Sung-Jan MD, PhD*,§,‖,¶; Chiu, Hsien-Yi MD, PhD*,§,**. Efficacy and Safety of a Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial. Dermatologic Surgery: November 2018 – Volume 44 – Issue 11 – p 1411-1420
- RCT
- n=100
- 24 weeks of treatment
- LLLT-treated scalp had significantly greater hair coverage (14.2% vs. 11.8%, p < .001).
- Significant improvement from baseline in the LLLT group noted study investigators
- hair thickness
- hair count
- hair coverage observed on the treated side than in the sham light-treated side at the 12- and 24-week visits.
- No serious adverse events were observed.
TRAUMATIC BRAIN INJURY
Figueiro Longo MG, Tan CO, Chan ST, et al. Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(9):e2017337. Published 2020 Sep 1. doi:10.1001/jamanetworkopen.2020.17337
NON-ALCOHOLIC FATTY LIVER DISEASE
NEUROLOGICAL
EYE
CARDIOVASCULAR/NITRIC OXIDE (NO)